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1.
Unfallchirurg ; 124(11): 945-950, 2021 Nov.
Artículo en Alemán | MEDLINE | ID: mdl-33416929

RESUMEN

Wearing a compression stocking over a longer period of time can lead to deep skin and soft tissue defects. This article presents a case of a circular necrosis with an exposed tendon of the tibialis anterior muscle and the Achilles tendon. The use of a peroneus brevis muscle flap led to an adequate coverage of the exposed Achilles tendon. Due to the short operating and anesthesia times, this flap is a good option for lower leg reconstruction, particularly in multimorbid patients. This case raises awareness of the importance of adequate patient training before commencing compression therapy.


Asunto(s)
Tendón Calcáneo , Procedimientos de Cirugía Plástica , Traumatismos de los Tejidos Blandos , Tendón Calcáneo/lesiones , Humanos , Pierna/cirugía , Traumatismos de los Tejidos Blandos/cirugía , Medias de Compresión , Colgajos Quirúrgicos
2.
Rev. bras. ortop ; 51(6): 630-639, Nov.-Dec. 2016. graf
Artículo en Inglés | LILACS | ID: biblio-830022

RESUMEN

ABSTRACT Foot and ankle fractures represent 12% of all pediatric fractures. Malleolar fractures are the most frequent injuries of the lower limbs. Hindfoot and midfoot fractures are rare, but inadequate treatment for these fractures may results in compartment syndrome, three-dimensional deformities, avascular necrosis and early post-traumatic arthritis, which have a significant impact on overall foot and ankle function. Therefore, the challenges in treating these injuries in children are to achieve adequate diagnosis and precise treatment, while avoiding complications. The objective of the treatment is to restore normal anatomy and the correct articular relationship between the bones in this region. Moreover, the treatment needs to be planned according to articular involvement, lower-limb alignment, ligament stability and age. This article provides a review on this topic and presents the scientific evidence for appropriate treatment of these lesions.


RESUMO As fraturas do tornozelo e do pé representam 12% de todas as fraturas pediátricas. Fraturas maleolares são as lesões mais frequentes dos membros inferiores; fraturas do retropé e mediopé são raras, mas o seu tratamento inadequado pode resultar em síndrome de compartimento, deformidades tridimensionais, necrose avascular e osteoartrose pós-traumática precoce, as quais apresentam impacto significativo na função global do tornozelo e pé. Portanto, os desafios no tratamento dessas lesões na criança são o diagnóstico adequado e tratamento preciso para se evitarem as complicações. O objetivo do tratamento é restaurar a anatomia normal e a relação articular correta entre os ossos da região. Além disso, o tratamento deve ser planejado de acordo com acometimento articular, o alinhamento dos membros inferiores, a estabilidade ligamentar e a idade. O algoritmo de tratamento dos traumas complexos do tornozelo e pé na infância é descrito. Este artigo apresenta uma revisão sobre o tema e as evidências científicas para o tratamento adequado dessas lesões.


Asunto(s)
Humanos , Masculino , Femenino , Niño , Articulación del Tobillo , Calcáneo , Astrágalo
3.
Foot Ankle Clin ; 21(1): 147-60, 2016 Mar.
Artículo en Inglés | MEDLINE | ID: mdl-26915785

RESUMEN

Treatment of malunion and nonunion at the Chopart joint aims at axial realignment of the midfoot to the hindfoot and restoration of the normal relationship of the lateral and medial columns of the foot. In carefully selected patients with intact cartilage, joint-preserving osteotomies are feasible at all 4 bony components of the Chopart joint to restore near-normal function. Priority should be given to the anatomic reconstruction of the talonavicular joint because it is essential for global foot function. Patients must be counseled about the risk of progressive arthritis or osteonecrosis necessitating late fusion.


Asunto(s)
Traumatismos de los Pies/cirugía , Fracturas Mal Unidas/cirugía , Fracturas no Consolidadas/cirugía , Articulaciones Tarsianas/cirugía , Traumatismos de los Pies/diagnóstico por imagen , Traumatismos de los Pies/fisiopatología , Fracturas Óseas/diagnóstico por imagen , Fracturas Óseas/fisiopatología , Fracturas Óseas/cirugía , Fracturas Mal Unidas/diagnóstico por imagen , Fracturas Mal Unidas/fisiopatología , Fracturas no Consolidadas/diagnóstico por imagen , Fracturas no Consolidadas/fisiopatología , Humanos , Osteotomía , Radiografía , Articulaciones Tarsianas/anatomía & histología , Articulaciones Tarsianas/lesiones , Articulaciones Tarsianas/fisiopatología
4.
Rev Bras Ortop ; 51(6): 630-639, 2016.
Artículo en Inglés | MEDLINE | ID: mdl-28050532

RESUMEN

Foot and ankle fractures represent 12% of all pediatric fractures. Malleolar fractures are the most frequent injuries of the lower limbs. Hindfoot and midfoot fractures are rare, but inadequate treatment for these fractures may results in compartment syndrome, three-dimensional deformities, avascular necrosis and early post-traumatic arthritis, which have a significant impact on overall foot and ankle function. Therefore, the challenges in treating these injuries in children are to achieve adequate diagnosis and precise treatment, while avoiding complications. The objective of the treatment is to restore normal anatomy and the correct articular relationship between the bones in this region. Moreover, the treatment needs to be planned according to articular involvement, lower-limb alignment, ligament stability and age. This article provides a review on this topic and presents the scientific evidence for appropriate treatment of these lesions.


As fraturas do tornozelo e do pé representam 12% de todas as fraturas pediátricas. Fraturas maleolares são as lesões mais frequentes dos membros inferiores; fraturas do retropé e mediopé são raras, mas o seu tratamento inadequado pode resultar em síndrome de compartimento, deformidades tridimensionais, necrose avascular e osteoartrose pós-traumática precoce, as quais apresentam impacto significativo na função global do tornozelo e pé. Portanto, os desafios no tratamento dessas lesões na criança são o diagnóstico adequado e tratamento preciso para se evitarem as complicações. O objetivo do tratamento é restaurar a anatomia normal e a relação articular correta entre os ossos da região. Além disso, o tratamento deve ser planejado de acordo com acometimento articular, o alinhamento dos membros inferiores, a estabilidade ligamentar e a idade. O algoritmo de tratamento dos traumas complexos do tornozelo e pé na infância é descrito. Este artigo apresenta uma revisão sobre o tema e as evidências científicas para o tratamento adequado dessas lesões.

5.
Foot Ankle Int ; 36(2): 211-24, 2015 Feb.
Artículo en Inglés | MEDLINE | ID: mdl-25583955

RESUMEN

BACKGROUND: Various ankle ligaments have different structural composition. The aim of this study was to analyze the morphological structure of ankle ligaments to further understand their function in ankle stability. METHODS: One hundred forty ligaments from 10 fresh-frozen cadaver ankle joints were dissected: the calcaneofibular, anterior, and posterior talofibular ligaments; the inferior extensor retinaculum, the talocalcaneal oblique ligament, the canalis tarsi ligament; the deltoid ligament; and the anterior tibiofibular ligament. Hematoxylin-eosin and Elastica van Gieson stains were used for determination of tissue morphology. RESULTS: Three different morphological compositions were identified: dense, mixed, and interlaced compositions. Densely packed ligaments, characterized by parallel bundles of collagen, were primarily seen in the lateral region, the canalis tarsi, and the anterior tibiofibular ligaments. Ligaments with mixed tight and loose parallel bundles of collagenous connective tissue were mainly found in the inferior extensor retinaculum and talocalcaneal oblique ligament. Densely packed and fiber-rich interlacing collagen was primarily seen in the areas of ligament insertion into bone of the deltoid ligament. CONCLUSIONS: Ligaments of the lateral region, the canalis tarsi, and the anterior tibiofibular ligaments have tightly packed, parallel collagen bundles and thus can resist high tensile forces. The mixed tight and loose, parallel oriented collagenous connective tissue of the inferior extensor retinaculum and the talocalcaneal oblique ligament support the dynamic positioning of the foot on the ground. The interlacing collagen bundles seen at the insertion of the deltoid ligament suggest that these insertion areas are susceptible to tension in a multitude of directions. CLINICAL RELEVANCE: The morphology and mechanical properties of ankle ligaments may provide an understanding of their response to the loads to which they are subjected.


Asunto(s)
Ligamentos Laterales del Tobillo/anatomía & histología , Articulación del Tobillo/fisiología , Fenómenos Biomecánicos/fisiología , Humanos , Ligamentos Laterales del Tobillo/fisiología
6.
Acta Biomater ; 10(6): 2855-65, 2014 Jun.
Artículo en Inglés | MEDLINE | ID: mdl-24534718

RESUMEN

Coating titanium implants with artificial extracellular matrices based on collagen and chondroitin sulfate (CS) has been shown to enhance bone remodelling and de novo bone formation in vivo. The aim of this study was to evaluate the effect of estrogen deficiency and hormone replacement therapy (HRT) on the osseointegration of CS-modified Ti implants. 30 adult female, ovariectomized Wistar rats were fed either with an ethinyl-estradiol-rich diet (E) to simulate a clinical relevant HRT or with a genistein-rich diet (G) to test an alternative therapy based on nutritionally relevant phytoestrogens. Controls (C) received an estrogen-free diet. Uncoated titanium pins (Ti) or pins coated with type-I collagen and CS (Ti/CS) were inserted 8weeks after ovarectomy into the tibia. Specimens were retrieved 28days after implantation. Both the amount of newly formed bone and the affinity index (P<0.05) were moderately higher around Ti/CS implants as compared to uncoated Ti. The highest values were measured in the G-Ti/CS and E-Ti/CS groups, the lowest values for the E-Ti and G-Ti controls. Quantitative synchrotron radiation micro-computed tomography (SRµCT) revealed the highest increase in total bone formation around G-Ti/CS as compared to C-Ti (P<0.01). The effects with respect to direct bone apposition were less pronounced with SRµCT. Using scanning nanoindentation, both the indentation modulus and the hardness of the newly formed bone were highest in the E-Ti/CS, G-Ti/CS and G-Ti groups as compared to C-Ti (P<0.05). Coatings with collagen and CS appear to improve both the quantity and quality of bone formed around Ti implants in ovarectomized rats. A simultaneous ethinyl estradiol- and genistein-rich diet seems to enhance these effects.


Asunto(s)
Remodelación Ósea , Sulfatos de Condroitina , Materiales Biocompatibles Revestidos , Ovariectomía , Prótesis e Implantes , Titanio , Animales , Femenino , Ratas , Ratas Wistar , Tibia
7.
Biomatter ; 42014.
Artículo en Inglés | MEDLINE | ID: mdl-24504113

RESUMEN

To investigate and assess bone regeneration in sheep in combination with new implant materials classical histological staining methods as well as immunohistochemistry may provide additional information to standard radiographs or computer tomography. Available published data of bone defect regenerations in sheep often present none or sparely labeled histological images. Repeatedly, the exact location of the sample remains unclear, detail enlargements are missing and the labeling of different tissues or cells is absent. The aim of this article is to present an overview of sample preparation, staining methods and their benefits as well as a detailed histological description of bone regeneration in the sheep tibia. General histological staining methods like hematoxylin and eosin, Masson-Goldner trichrome, Movat's pentachrome and alcian blue were used to define new bone formation within a sheep tibia critical size defect containing a polycaprolactone-co-lactide (PCL) scaffold implanted for 3 months (n = 4). Special attention was drawn to describe the bone healing patterns down to cell level. Additionally one histological quantification method and immunohistochemical staining methods are described.


Asunto(s)
Regeneración Ósea/fisiología , Sustitutos de Huesos/química , Prótesis e Implantes , Actinas/metabolismo , Animales , Femenino , Músculo Liso/metabolismo , Poliésteres/química , Ovinos , Coloración y Etiquetado/métodos , Tibia/patología , Tibia/cirugía , Andamios del Tejido/química
8.
J Biomater Appl ; 28(5): 654-66, 2014 Jan.
Artículo en Inglés | MEDLINE | ID: mdl-23413230

RESUMEN

The aim of this pilot study was to evaluate the bioactive, surface-coated polycaprolactone-co-lactide scaffolds as bone implants in a tibia critical size defect model. Polycaprolactone-co-lactide scaffolds were coated with collagen type I and chondroitin sulfate and 30 piled up polycaprolactone-co-lactide scaffolds were implanted into a 3 cm sheep tibia critical size defect for 3 or 12 months (n = 5 each). Bone healing was estimated by quantification of bone volume in the defects on computer tomography and microcomputer tomography scans, plain radiographs, biomechanical testing as well as by histological evaluations. New bone formation occurred at the proximal and distal ends of the tibia in both groups. The current pilot study revealed a mean new bone formation of 63% and 172% after 3 and 12 months, respectively. The bioactive, surface coated, highly porous three-dimensional polycaprolactone-co-lactide scaffold stack itself acted as a guide rail for new bone formation along and into the implant. These preliminary data are encouraging for future experiments with a larger group of animals.


Asunto(s)
Materiales Biocompatibles Revestidos , Poliésteres , Andamios del Tejido , Cicatrización de Heridas , Animales , Ovinos , Propiedades de Superficie , Microtomografía por Rayos X
9.
Clin Orthop Relat Res ; 471(9): 2885-98, 2013 Sep.
Artículo en Inglés | MEDLINE | ID: mdl-23690151

RESUMEN

BACKGROUND: The treatment of displaced, intraarticular calcaneal fractures (DIACFs) remains challenging and the best treatment choices remain controversial. The majority of patients will have some lasting functional restrictions. However, it is unclear which patient- or surgeon-related factors predict long-term function. QUESTIONS/PURPOSES: We determined (1) the impact of patient- and surgeon-related factors on function of patients after internal fixation of DIACFs and (2) whether severity of injury correlated with subsequent function. METHODS: We retrospectively reviewed all 210 patients operatively treated for 242 DIACFs between 2000 and 2003; of these, 127 patients (60%) with 149 fractures were available for followup at a minimum of 69 months (average, 95 months; range, 69-122 months). Severity of injury was quantified by the classifications of Sanders and Zwipp Function was quantified using the American Orthopaedic Foot and Ankle Society (AOFAS) Ankle-Hindfoot score, an adjusted Zwipp score, the Foot Function Index (FFI), and the SF-36 physical and mental component summary (PCS and MCS) scores. RESULTS: At latest followup, the median AOFAS score was 77, the median Zwipp score was 60, the median FFI was 27, and the median SF-36 PCS and MCS scores were 44 and 55, respectively. The foot-related scores and the SF-36 PCS negatively correlated with the severity of injury, work-related injuries, and bilateral fractures. CONCLUSIONS: We found the severity of a DIACF related to subsequent foot function and quality of life. Both fracture severity classifications predicted function. Anatomic reconstruction of the shape and articular surfaces of the calcaneus leads to predictable function in the medium to long term.


Asunto(s)
Calcáneo/lesiones , Traumatismos de los Pies/cirugía , Fracturas Óseas/cirugía , Fracturas Intraarticulares/cirugía , Adolescente , Adulto , Anciano , Calcáneo/cirugía , Femenino , Estudios de Seguimiento , Traumatismos de los Pies/fisiopatología , Fracturas Óseas/fisiopatología , Humanos , Puntaje de Gravedad del Traumatismo , Fracturas Intraarticulares/fisiopatología , Masculino , Persona de Mediana Edad , Recuperación de la Función , Estudios Retrospectivos , Resultado del Tratamiento
10.
Mater Sci Eng C Mater Biol Appl ; 32(7): 1926-1930, 2012 Oct 01.
Artículo en Inglés | MEDLINE | ID: mdl-34062677

RESUMEN

Chondroitin sulfate (CS) has anti-inflammatory properties and increases the regeneration ability of injured bone. In different in vivo investigations on bone defects the addition of CS to calcium phosphate bone cement has lead to an enhanced bone remodeling and increased new bone formation. The goal of this study was to evaluate the cellular effects of CS on human mesenchymal stem cells (hMSCs). In cell culture experiments hMSCs were incubated on calcium phosphate bone cements with and without CS and cultivated in a proliferation and an osteogenetic differentiation media. Alkaline phosphatase and the proliferation rate were determined on days 1, 7 and 14. Concerning the proliferation rates, no significant differences were detected. On days 1, 7 and 14 a significantly higher activity of alkaline phosphatase, an early marker of osteogenesis, was detected around CS modified cements in both types of media. The addition of CS leads to a significant increase of osteogenetic differentiation of hMSCs. To evaluate the influence of the osteoconductive potency of CS in twelve adult male Wistar rats, the interface reaction of cancellous bone to a nanocrystalline hydroxyapatite cement containing type I collagen (CDHA/Coll) without and with CS (CDHA/Coll/CS) was evaluated. Cylindrical implants were inserted press-fit into a defect of the tibial head. 28days after the operation the direct bone contact and the percentage of newly formed bone were significantly higher on CDHA/Coll/CS-implants (p<0.05). The addition of CS appears to enhance new bone formation on CDHA/Coll-composites in the early stages of bone healing. Possible mechanisms are discussed.

11.
Biomatter ; 2(3): 158-65, 2012.
Artículo en Inglés | MEDLINE | ID: mdl-23507867

RESUMEN

Tissue engineering and regenerative techniques targeting bone include a broad range of strategies and approaches to repair, augment, replace or regenerate bone tissue. Investigations that are aimed at optimization of these strategies until clinical translation require control of systemic factors as well as modification of a broad range of key parameters. This article reviews a possible strategy using a tissue engineering approach and systematically describes a series of experiments evaluating the properties of an embroidered and surface coated polycaprolactone-co-lactide scaffold being considered as bone graft substitute for large bone defects. The scaffold design and fabrication, the scaffolds properties, as well as its surface modification and their influence in vitro are evaluated, followed by in vivo analysis of the scaffolds using orthotopic implantation models in small and large animals.


Asunto(s)
Huesos/química , Poliésteres/química , Ingeniería de Tejidos/métodos , Animales , Regeneración Ósea , Sustitutos de Huesos , Adhesión Celular , Humanos , Ensayo de Materiales , Osteogénesis , Prótesis e Implantes , Diseño de Prótesis , Ratas , Ovinos , Factores de Tiempo , Andamios del Tejido
12.
Biomatter ; 2(3): 149-57, 2012.
Artículo en Inglés | MEDLINE | ID: mdl-23507866

RESUMEN

Coatings of orthopedic implants are investigated to improve the osteoinductive and osteoconductive properties of the implant surfaces and thus to enhance periimplant bone formation. By applying coatings that mimic the extracellular matrix a favorable environment for osteoblasts, osteoclasts and their progenitor cells is provided to promote early and strong fixation of implants. It is known that the early bone ongrowth increases primary implant fixation and reduces the risk of implant failure. This review presents an overview of coating titanium and hydroxyapatite implants with components of the extracellular matrix like collagen type I, chondroitin sulfate and RGD peptide in different small and large animal models. The influence of these components on cells, the inflammation process, new bone formation and bone/implant contact is summarized.


Asunto(s)
Sustitutos de Huesos , Huesos/patología , Materiales Biocompatibles Revestidos/química , Animales , Diferenciación Celular , Proliferación Celular , Sulfatos de Condroitina/química , Colágeno/química , Citocinas/metabolismo , Durapatita/química , Matriz Extracelular/metabolismo , Fémur/patología , Humanos , Implantes Experimentales , Oligopéptidos/química , Oseointegración , Osteoblastos/citología , Osteoclastos/citología , Prótesis e Implantes , Ratas , Tibia/patología , Titanio/química
13.
Arthroscopy ; 27(7): 1014-7, 2011 Jul.
Artículo en Inglés | MEDLINE | ID: mdl-21616628

RESUMEN

Subcutaneous emphysema of the upper extremity is rare. Crepitation on physical examination and visible gas on radiographs raise the concern of gas gangrene due to gas-producing bacteria. Rapid establishment of a differential diagnosis is necessary to initiate proper treatment. We present a case of subcutaneous emphysema after elbow arthroscopy caused by a noninfectious genesis. A 59-year-old woman with loose bodies in her left elbow due to mild degenerative joint disease and restricted range of motion was offered an elbow arthroscopy with removal of loose bodies and arthrolysis. Postoperatively, the elbow was actively put alternatively in maximum extension and flexion. On the first postoperative day, rapidly ascending swelling and subcutaneous crepitation starting from the hand to the forearm were noted. There was no clinical evidence of infection. Radiographs showed subcutaneous air. Frequent blood tests and clinical evaluation ruled out a potentially life-threatening bacterial infection, and the signs resolved after 1 week without surgical treatment. Presumably, the intensive postoperative range-of-motion exercises led to a sucking in of air into the wound during each movement. This case illustrates that it is important to differentiate nonbacterial from bacterial causes of soft-tissue gas formation to initiate the appropriate treatment.


Asunto(s)
Brazo , Artroscopía , Articulación del Codo/cirugía , Cuerpos Libres Articulares/complicaciones , Cuerpos Libres Articulares/cirugía , Enfisema Subcutáneo/etiología , Antibacterianos/administración & dosificación , Antiinfecciosos/administración & dosificación , Infecciones Bacterianas/prevención & control , Diagnóstico Diferencial , Esquema de Medicación , Combinación de Medicamentos , Articulación del Codo/diagnóstico por imagen , Articulación del Codo/patología , Terapia por Ejercicio/efectos adversos , Femenino , Humanos , Inyecciones Intravenosas , Cuerpos Libres Articulares/patología , Metronidazol/administración & dosificación , Persona de Mediana Edad , Penicilina G/administración & dosificación , Cuidados Posoperatorios/efectos adversos , Radiografía , Rango del Movimiento Articular , Enfisema Subcutáneo/diagnóstico por imagen
14.
Arch Orthop Trauma Surg ; 131(8): 1043-52, 2011 Aug.
Artículo en Inglés | MEDLINE | ID: mdl-21331548

RESUMEN

OBJECTIVE: The aim of this study was to compare the functional ankle stability between professional and amateur soccer players as well as controls. MATERIALS AND METHODS: Thirty professional soccer players, 30 amateur soccer players and 30 controls were evaluated. All participants completed a questionnaire. Range of motion (ROM), peroneal reaction time (PRT) and ankle position sense were measured. Balance control was investigated with the Biodex Stability System, measuring the stable level 8 and the unstable level 2. RESULTS: Professional soccer players cited significantly more frequent ankle sprains than all other groups (P = 0.002). They showed a significantly decreased dorsiflexion of the right foot (amateur: P = 0.017; controls: P = 0.004), an increased pronation of both feet (amateurs: right: P = 0.0048, left: P = 0.006; controls: right: P = 0.017, left: P = 0.007) and a decreased supination of the left foot in comparison to all other groups (amateurs: P = 0.003; controls: P = 0.004). Balance control showed no significant differences among all groups. Significant differences in angle reproduction were observed between professionals and amateurs for the left ankle joint at the positions of 105° (P = 0.0018) and 140° (P = 0.013). Professionals (P = 0.004) and amateurs (P = 0.001) showed a significantly delayed PRT of the right peroneus longus muscle compared to controls. In addition, the PRT of the right peroneus brevis muscle was significantly increased in professional soccer players in comparison to controls (P = 0.017). CONCLUSIONS: Professional soccer players have shown more frequent ankle sprains, limited ROM, and delayed PRT of the right leg which reflects the higher risk of functional ankle instability due to intensified work-related use of feet. Therefore, proprioceptive exercises of the ankle in daily training programs are recommended in order to minimize the risk of ankle injuries and improve functional ankle stability.


Asunto(s)
Articulación del Tobillo/fisiología , Atletas , Fútbol/fisiología , Adulto , Traumatismos del Tobillo/epidemiología , Articulación del Tobillo/fisiopatología , Femenino , Humanos , Inestabilidad de la Articulación/fisiopatología , Masculino , Equilibrio Postural , Propiocepción , Rango del Movimiento Articular , Esguinces y Distensiones/epidemiología , Encuestas y Cuestionarios
15.
Eur J Trauma Emerg Surg ; 36(3): 196-205, 2010 Jun.
Artículo en Inglés | MEDLINE | ID: mdl-26815862

RESUMEN

Fractures and dislocations at the mid-tarsal (Chopart) joint are frequently overlooked or misinterpreted at first presentation. Inadequate joint reduction and stabilization almost invariably lead to painful malunions or nonunions, residual instability, and deformity. Because of the central position and the essential function of the mid-tarsal joint, malunions lead to a considerable impairment of global foot function and the rapid development of posttraumatic arthritis. While secondary anatomical reconstruction with joint preservation would be desirable in order to restore normal foot function, it is amenable only if no symptomatic arthritis or avascular necrosis is present. Over a course of 6 years, eight patients have been treated with secondary correction, joint realignment, and internal fixation. In four of these cases, nonunions of the tarsal navicular were debrided and bone-grafted; in the remaining cases, a corrective osteotomy at the navicular or cuboid was carried out. At 2 years followup, all but one patient were satisfied with the result. One patient underwent fusion of the talonavicular joint for avascular necrosis and collapse of the navicular. The mean American Orthopaedic Foot and Ankle Score (AOFAS) improved significantly from 38.8 preoperatively to 80.8 at follow-up. However, the majority of malunited mid-tarsal fracture-dislocations will require corrective fusion of the affected joint(s) with axial realignment because of manifest posttraumatic arthritis at the time of patient presentation.

16.
J Orthop Res ; 27(1): 15-21, 2009 Jan.
Artículo en Inglés | MEDLINE | ID: mdl-18634066

RESUMEN

The addition of chondroitin sulphate (CS) to bone cements with calcium phosphate has lead to an enhancement of bone remodeling and an increase in new bone formation in small animals. The goal of this study was to verify the effect of CS in bone cements in a large animal model simulating a clinically relevant situation of a segmental cortical defect of a critical size on bone-implant interaction and bone remodeling. The influence of adding CS to hydroxyapatite/collagen (HA/Col) composites on host response was assessed in a standard sheep tibia model. A midshaft defect of 3 cm was created in the tibiae of 14 adult female sheep. The defect was filled with a HA/Col cement cylinder in seven animals and with a CS-modified hydroxyapatite/collagen (HA/Col/CS) cement cylinder in seven animals. In all cases the tibia was stabilized with an interlocked universal tibial nail. The animals in each group were analyzed with X-rays, CT scans, histology, immunohistochemistry, and enzymehistochemistry, as well as histomorphometric measurements. The X-ray investigation showed a significantly earlier callus reaction around the HA/Col/CS implants compared to HA/Col alone. The amount of newly formed bone at the end point of the experiment was significantly larger around HA/Col/CS cylinders both in the CT scan and in the histomorphometric analysis. There were still TRAP-positive osteoclasts around the HA/Col implants after 3 months. The number of osteopontin-positive osteoblasts and the direct bone contact were significantly higher around HA/Col/CS implants. We conclude that addition of CS enhances bone remodeling and new bone formation around HA/Col composites.


Asunto(s)
Remodelación Ósea , Sustitutos de Huesos/química , Sulfatos de Condroitina/química , Colágeno/química , Durapatita/química , Tibia/metabolismo , Animales , Cementos para Huesos/química , Huesos/metabolismo , Femenino , Inmunohistoquímica/métodos , Osteoblastos/metabolismo , Osteopontina/química , Ovinos , Tomografía Computarizada por Rayos X
17.
Arch Orthop Trauma Surg ; 129(8): 1089-92, 2009 Aug.
Artículo en Inglés | MEDLINE | ID: mdl-18818936

RESUMEN

BACKGROUND: Lacking rational basis for the postoperative treatment of fifth metatarsal avulsion fractures. METHODS: Biomechanical test of stability of tension banding and screw fixation of fifth metatarsal avulsion fractures in cadaver specimen, sonographic measuring of the maximum cross-section of the peroneus brevis muscle, electromyographic examinations of the activity of the peroneus brevis muscle at different loads and means of immobilization. RESULTS: The forces acting on the base of the fifth metatarsal bone during voluntary activation of the peroneus brevis muscle or activation in the gait cycle are of the same magnitude as the failure forces of internal fixation. Immobilization of the talocrural joint achieves no reduction in muscle activation. Partial weight bearing reduces muscle activation. CONCLUSIONS: The postoperative treatment after osteosynthesis of fifth metatarsal avulsion fractures should be partial weight bearing. For safety reasons we add an elastic ankle orthesis to prevent supination. A below-knee cast is not necessary.


Asunto(s)
Fracturas Óseas/cirugía , Huesos Metatarsianos/cirugía , Adulto , Anciano , Fenómenos Biomecánicos , Cadáver , Humanos , Masculino , Persona de Mediana Edad , Músculo Esquelético/fisiopatología , Cuidados Posoperatorios , Soporte de Peso
18.
Acta Orthop ; 79(2): 225-9, 2008 Apr.
Artículo en Inglés | MEDLINE | ID: mdl-18484248

RESUMEN

BACKGROUND: A standard ilioinguinal approach is often insufficient for reduction and stabilization of the medial acetabular wall and the dorsal column in acetabular fractures. To avoid extended approaches, we have used a medial extension of the approach by transverse splitting of the rectus abdominis muscle. We have thus been able to reduce and stabilize transverse and oblique fractures of the dorsal column and the medial acetabular wall and to fix plates in a mechanically better position below the pelvic brim. To evaluate the procedure, especially the risk of abdominal hernia, we started a prospective study. PATIENTS AND METHODS: Over 2 years, we treated 21 consecutive patients using a transverse splitting of the rectus abdominis muscle-either as an extension of the standard ilioinguinal approach or in combination with parts of this approach or a Kocher-Langenbeck approach. The patients were evaluated clinically and radiographically after 1 year. RESULTS: The clinical and radiographic results were excellent or good in 18 patients. Complications occurred in 5 patients. No hernias were observed. CONCLUSIONS: Our small study indicates that the procedure described is a useful and safe complement to the intrapelvic approaches. The procedure does not provide better reduction than extended approaches, but may help to avoid them in some cases.


Asunto(s)
Acetábulo/lesiones , Fijación Interna de Fracturas/métodos , Fracturas Óseas/cirugía , Recto del Abdomen/cirugía , Acetábulo/cirugía , Adulto , Anciano , Femenino , Fijación Interna de Fracturas/efectos adversos , Humanos , Masculino , Persona de Mediana Edad , Estudios Prospectivos , Resultado del Tratamiento
19.
J Biomed Mater Res A ; 85(3): 638-45, 2008 Jun 01.
Artículo en Inglés | MEDLINE | ID: mdl-17806118

RESUMEN

Chondroitin sulphate (CS) has an anti-inflammatory effect and increases the regeneration ability of injured bone. The goal of this study was to characterize the material properties and osteoconductive potency of calcium phosphate bone cements modified with CS. The early interface reaction of cancellous bone to a nanokristalline hydroxyapatite cement containing type I collagen (HA/Coll) without and with CS (HA/Coll/CS) in a rat tibia model was evaluated. Cylindrical implants were inserted press-fit into defect of the tibial head. Six specimens per group were analyzed at 2, 4, 7, 14, and 28 days. HA/Coll/CS composite cylinders showed a 15% increase in compressive strength and by investigations with powder X-ray diffraction more nontransformed cement precursor was found. The microstructures of both types of implants were similar. A significantly higher average number of TRAP positive osteoclasts and ED1 positive mononuclear cells were observed in the interface around HA/Coll/CS implants on day 4 and 7 (p < 0.05). At 28 days the direct bone contact and the percentage of newly formed bone were significantly higher around HA/Coll/CS implants (p < 0.05). The addition of CS appears to enhance bone remodelling and new bone formation around HA/Coll composites in the early stages of bone healing. Possible mechanisms are discussed.


Asunto(s)
Cementos para Huesos/química , Remodelación Ósea/efectos de los fármacos , Sulfatos de Condroitina/farmacología , Animales , Materiales Biocompatibles , Regeneración Ósea , Colágeno Tipo I , Hidroxiapatitas , Ensayo de Materiales , Osteoclastos/citología , Ratas , Tibia
20.
J Hand Surg Am ; 32(7): 954-61, 2007 Sep.
Artículo en Inglés | MEDLINE | ID: mdl-17826546

RESUMEN

PURPOSE: The aim of this study was to define the outcome after dorsal or volar plating of Association for Osteosynthesis (AO) type C3 distal radius fractures based on the fracture morphology. METHODS: Twenty-nine patients with AO type C3 distal radius fractures were surgically managed between 1996 and 2005. Group 1 (n = 15) had volar plating. Group 2 (n = 14) had dorsal plating. Outcomes were evaluated at an average of 22 months after surgery. Statistical analysis was performed using the Wilcoxon test and chi-square test. RESULTS: No significant differences were seen for the scores of Gartland and Werley, Castaing, Stewart I and II, Green and O'Brien, and Disability of the Arm, Shoulder and Hand between the 2 groups. The visual and verbal pain analog scales did not show significant differences between the 2 groups. Radiology analysis showed significant difference in comparison with the contralateral side in terms of dorsopalmar inclination (3 degrees +/- 3) and distal radioulnar joint angle (98 degrees +/- 8) for the patients in group 1, whereas there were no significant differences in group 2. The development of radiographic post-traumatic arthritis was significant in both groups. Significant functional differences were seen for flexion (45 degrees +/- 15) and hand span (20 cm +/- 2) in group 1 as well as for extension (37 degrees +/- 19), flexion (42 degrees +/- 12), and radial deviation (16 degrees +/- 10) in group 2. We found more complications after dorsal plate osteosynthesis than after volar plate osteosynthesis. CONCLUSIONS: This study shows satisfactory functional and subjective outcome results in both groups. Group 1 had non-significant better functional results than group 2, whereas both groups showed good to very good radiology results.


Asunto(s)
Fijación Interna de Fracturas/métodos , Fracturas del Radio/cirugía , Artritis/etiología , Placas Óseas , Evaluación de la Discapacidad , Femenino , Curación de Fractura , Humanos , Masculino , Persona de Mediana Edad , Dimensión del Dolor , Radiografía , Fracturas del Radio/complicaciones , Fracturas del Radio/diagnóstico por imagen , Rango del Movimiento Articular , Estudios Retrospectivos , Resultado del Tratamiento , Articulación de la Muñeca/diagnóstico por imagen , Articulación de la Muñeca/cirugía
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